Acoramidis Associated with Significantly Improved Clinical Outcomes Versus Tafamidis in ATTR-CM in an Independent, Real-World Study of U.S. Electronic Health Records

An independent real-world study of 2,684 ATTR-CM patients from U.S. electronic health records found that acoramidis was associated with an 18% lower risk of death, hospitalization, atrial fibrillation, and diuretic intensification compared to tafamidis. Acoramidis showed 27% lower risk of cardiovascular and heart failure hospitalizations. These findings replicate earlier comparative effectiveness analyses and support acoramidis as a preferred stabilizer treatment option.