Gilead And Merck End Trodelvy-Keytruda Lung Cancer Trial

Gilead Sciences and Merck discontinued their Phase 3 KEYNOTE-D46/EVOKE-03 trial evaluating Trodelvy plus Keytruda for lung cancer after the combination failed to reach statistical significance in progression-free survival with low probability of overall survival benefit. However, the companies reported positive Phase 3 results for an investigational once-weekly oral HIV regimen combining islatravir and lenacapavir, which met its primary efficacy endpoints in two studies.